Showing posts with label intelligence. Show all posts
Showing posts with label intelligence. Show all posts

Wednesday, March 02, 2011

Szilard, science fiction, dolphins and EMBL

In retrospect, it would appear that among the various recommendations made by the President's Science Advisory Committee there was only one which has borne fruit. At some point or other, the Committee had recommended that there be set up, at the opportune time, a major joint Russian-American research project having no relevance to the national defense, or to any politically controversial issues. The setting up in 1963 of the Biological Research Institute in Vienna under a contract between the Russian and American governments was in line with the general recommendation of the Committee.
[...]

This was generally regarded at that time as a major setback for this young branch of science, in Russia as well as in America, and there were those who accused Sergei Dressler of having played the role of the Pied Piper. There may have been a grain of truth in this accusation, inasmuch as a conference on molecular biology held in Leningrad in 1962 was due to his initiative. Dressler spent a few months in America in 1960 surveying the advances in molecular biology. He was so impressed by what he saw that he decided to do something to stimulate this new branch of science in his native Russia. The Leningrad Conference was attended by many Americans; it was the first time that American and Russian molecular biologists came into contact with each other, and the friendships formed on this occasion were to last a lifetime.

~ "Voice of the Dolphins" by Leo Szilárd (1961)
The science fiction story "Voice of the Dolphins" was published by Leo Szilárd in 1961. As you can probably tell from the above excerpt, the writing is pretty dry. Szilárd certainly wasn't known for his fiction, even during his lifetime. But Szilárd - and his tale - did play an important role in the establishment of the European Molecular Biology Laboratory (EMBL), an international research institute in Heidelberg, Germany.

Leo Szilárd was a Hungarian-born physicist who was one of the fathers of both nuclear energy and nuclear weapons.  Szilárd was one of the first scientists to conceive the nuclear chain reaction. After emigrating to the United States in 1938, he worked with Enrico Fermi at Columbia University in New York. Together they figured out how to make the nuclear reaction self-sustaining, and ultimately  patented a nuclear reactor based on their research.

It was a 1939 letter drafted by Szilárd and signed by his friend Albert Einstein, that helped convince President Roosevelt that Nazi Germany might be able to construct nuclear weapons. That lead to the creation of the Manhattan Project, which ultimately did develop the first atomic bomb.

Szilárd was apparently horrified by the dropping of the atomic bombs on the civilian populations of Hiroshima and Nagasaki. After the end of World War II he became a strong advocate for arms control, and corresponded with Nikita Khrushchev for several years trying to set up informal U.S.-Soviet disarmament discussions.

He also shifted his research from nuclear physics to molecular biology. He was one of several of mid-20th century physicists to take an interest in this young field that was starting to decipher the molecular underpinnings of genetics. Szilárd worked closely with fellow former Manhattan Project physicist Aaron Novik, who would later found the Institute of Molecular Biology at the University of Oregon.

Szilárd apparently wrote science fiction stories as an expression of his more utopian political ideas. After one of his non-fiction articles about arms control was rejected for publication, he reportedly commented "If they cannot take it straight, they'll get it in fiction."

He published a collection of his stories in 1961. The title story of that collection, "Voice of the Dolphins", is set in a future where American and Russian scientists have come together to establish an international biological institute in Vienna to study dolphins. 

The science fictional twist is that dolphins turn out to be more intelligent than anticipated - smarter than humans, in fact.
Having learned the language of the dolphins and established communication with them, the staff of the Institute began to teach them first mathematics, next chemistry and physics, and subsequently biology. The dolphins acquired knowledge in all of these fields with extraordinary rapidity. Because of their lack of manual dexterity the dolphins were not able to perform experiments. In time, however, they began to suggest to the staff experiments in the biological field, and soon thereafter it became apparent that the staff of the Institute might be relegated to performing experiments thought up by the dolphins.

It's not a particularly gripping story - Szilárd was a vastly better scientist than he was a fiction writer - but I like it's optimistic view that scientists working together could overcome Cold War animosities.

The great thing about Szilárd was that he wasn't just dreamer, he was a a man of action. In late 1962 he met with fellow physicists Victor Weisskopf (like Szilard a former Manhattan Project physicist and campaigner against nuclear proliferation) and Gilberto Bernardini to discuss the creation of a real international biological research lab. They, in turn, called on their molecular biologist colleagues James Watson and John C. Kendrew, who both 1962 Nobel Prize laureates, to help make their plan a reality.

Out of that and subsequent meetings arose the European Molecular Biology Organization (EMBO). And, after more than a decade of planning, the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany was finally established in 1974 with John Kendrew as its first director.

Szilárd died in 1964, so he never saw his imagined "Biological Research Institute" become a reality. However, in memory of his role in its foundation, the EMBL library was named in his honor. And in honor of the story that helped inspired it all, they adopted the symbol of the dolphin on its book plates as as its logo. The original logo is shown above. It was replaced with a more stylized logo a few years ago.



 Hopefully it serves as a reminder to the library's users of Leo Szilard and his dream of peaceful scientific collaboration.

Considering Szilárd's importance as a brilliant scientist, Cold War peace activist, and proponent of international scientific cooperation, I'm a bit embarrassed to admit that the story of his accomplishments was mostly new to me.  My post barely scratches the surface of his life. If you are interested in learning more about Szilárd, I recommend starting here:

EMBL Library - About the Library - About Leo Szilárd
Leo Szilárd Online
• Bess, M. "Leo Szilard: scientist, activist, visionary" Bulletin of the Atomic Scientists 3(3): 11-17 (1985)


Many thanks to Anne Barkworth at the Szilard Library for copies of the dolphin logo and permission to reproduce them.

Photo of Leo Szilárd from the Department of Energy Digital Photo Archive

Monday, March 30, 2009

Beast Men and other Bio Horror SF at Apex Magazine

There is something about the nature of biology - growing things, squishy internal organs, monsters and mutants - that lends itself to the horror end of the science fiction spectrum. And they aren't always just chilling entertainment; such horrifying stories can be used to look at philosophical questions about what it means to be human. The March 3rd edition of Apex Magazine ("where science fiction and horror collide") has a couple of good examples of that this month. As Sarah Brandel writes in her introductory essay "Beast Men and the Human Animal":
Another facet of the question ‘What is human?’ addresses the differences between human beings and other members of the animal kingdom. If, in some respects, tiny variations in DNA are all that separate human beings physically from their closest primate relatives, where is the genetic line drawn between what is human and what is not? (There are easy answers from a species perspective—only members of the same species can produce viable offspring—but we’re not looking for easy answers here.)
I won't quote any more, because there are spoilers for the stories, but you can read them online yourself:
And for some more good creepiness, here are a couple of other biology-science fiction-horror stories from their archives:
(And if you enjoy what you read at Apex, consider clicking on their "Donate" button and making a small contribution.)

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Tuesday, March 24, 2009

David Brin on Uplift

While David Brin has written many fine novels, I think the most interesting are those set in his "Uplift universe", in which "patron" species in the intergalactic civilization genetically modify non-sapient "client" species to bring them sapience. In this universe humans have uplifted and work side-by-side with chimpanzees and dolphins. (You can read two Uplift Universe short stories for free on Brin's web site.)

This week David Brin is guest blogging at George Dvorsky's Sentient Developments. Dvorsky is quite interested in ethical issues around the uplift of nonhuman animals, and has asked Brin to share his thoughts on whether this is something we should or even could do. In his first post, Brin does just that. He also writes a bit about why his take is different than that of The Island of Doctor Moreau or Planet of the Apes:
The notion that we would abuse or enslave such creatures has some deep metaphorical resonance -- and during a long transition they would not be our peers. But as a goal? A reason to create new beings? It really is kind of pathetic, as are the simplistic tales.

I wanted, instead, to explore what might happen if we took on such a challenge with the BEST of intentions! Wouldn't the new species have problems anyway? Problems that are much more subtle and interesting than mere oppression?
And it raises many questions as to what the situation might be like from the uplifted species' point-of-view, something Brin likes to explore:
I get to stretch my imagination, and the reader's, exploring what sapient dolphins or chimps might feel and think, under the pressure of such development, tugged between both the ancient instincts of their forebears and the new template being imposed upon them by their "patrons."
It's been many years since I read Startide Rising, and this makes me want to go back and read it again. Go read Brin's whole post!

Also, in a related post, Dvorsky suggests checking out the work of Sue Savage-Rumbaugh at the Great Ape Trust to learn more about the possible cultural issues of uplift:
Just to be clear, Sue is not an advocate of biological uplift, but the work that she does integrating bonobos into non-traditional living environments and in comprehending their language and culture speaks directly to this issue; there's a very fine line between cultural and biological uplift. For starters, check out the article, "Sue Savage-Rumbaugh on the welfare of apes in captivity." Also be sure to check out the work of the Great Ape Trust.
I have mixed feelings about some of Dvorsky's arguments about non-human animal culture, but I do think it's an interesting and important topic to consider. I'm looking forward to reading more posts by Brin at Sentient Developments this week.







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Sunday, January 11, 2009

Kyle XY and Einstein's Brain


ABC Family's Kyle XY is one of those shows that sounds interesting, but I've never quite gotten around to actually watching. Maybe it's because ABC Family isn't one of the stations that's on my schedule radar, or maybe it's because the teen angst aspect of the show makes it less appealing than the other shows in its time slot. In any case, the new season starts Monday, and I thought it was high time that I looked at a bit of the biology behind the show. Forgive me (and feel free to leave a comment) if I get part of the storyline wrong .

Here's the general premise of the show: Hunky 26-year old Matt Dallas plays teenager Kyle, who one day wakes up naked and belly button-less in the forest with no memory of his childhood. He's an innocent who needs to learn to learn everything: from learning to speak to simple social interactions, all while trying to discover who he is. Of course it helps that has superior mental and physical skills.

During the first two seasons, Kyle's origins are revealed: he's a clone - subject 781227 - who is part of an experimental program funded by the Zzyzx Corporation to develop super soldiers. At this summer's Comic-Con, io9 interviewed Matt Davis about the show. He talks a bit about Kyle's origins, and suggests that Season 3 (which premiers Monday) will delve heavily into science.

So what sets Kyle apart from your usual supergenius clone? It all started with Albert Einstein. You see, Einstein supposedly spend an extra three weeks in the womb, which allowed his brain to develop further in utero than usual. The result was that he became a physics genius - and started a research program to create others like him. Kyle is one of the latest results of that many-decade long research project. He actually spent 16 years in an artificial womb which allowed him to develop high intelligence, telepathy and other mental skills. It also explains his lack of a belly button.

Now is this based on real science? Not really, as far as I can tell.

- Did Einstein spend an extra 3 weeks in the womb?

I couldn't find any mention of anything unusual about Einstein's birth in any of the biographies I browsed online or on Google Books. It's possible that his birth was later than expected, but I would think that even in the 19th century a pregnancy three weeks past its due date would have been a serious cause for concern. The doctor or midwife attending Einstein's mother would likely have tried to induce childbirth before that time. Today doctors usually induce labor when pregnancy continues two weeks beyond the due date.

- Was Einstein's brain special?

As a boy, Einstein excelled at mathematics, solving problems far above his grade level. However, that aptitude didn't extend to every subject. Einstein's parents supposedly consulted a doctor about his slow verbal development. Even at the age of nine he had difficultly speaking. That may have made him seem slow to his teachers and family. It doesn't seem that anyone expected him to end up an icon of scientific genius.

We actually know a lot about Einstein's brain. Since his death in 1955 it has been analyzed by a number of neuroanatomists. While we still don't understand what made Einstein a genius, it appears that his brain differed from the average in several ways:
So what does all of this mean? One suggestion is that Einstein's abilities were due to the fact that the parts of the brain involved in language were smaller than than typical, which allowed parts of his brain involved in processing numbers and spatial relationships to grow larger. That's highly speculative, though, and we may never really know the answer.

One thing is clear: Einstein's brain doesn't appear to have developed more than usual, just differently from average.

- So could extended development in the womb increase intelligence?

Einstein is really only a small part of the Kyle XY mythos. The real biological claim is that Kyle has extraordinary abilities because he remained the equivalent of "in utero" for sixteen years. Is that possible? I don't think so. Human intelligence is determined by a complex set of factors, including genetics, nutrition, and other environmental factors. The connections between neurons in our brain are set in response to training and education, particularly during childhood. That means that it's unlikely that Kyle would develop into a genius would develop without some sort of outside stimulation. And if Kyle wasn't exposed to language in the early years of his life, it's unlikely that he would be able to learn to speak normally at all.

I'd be interested in hearing from any of you readers that have seen the show about what Kyle's development was actually supposed to be like. Was he really isolated in an artifical womb? or was he actually allowed to grow up in some sort of accelerated learning environment? Perhaps that's what will be shown in the show's upcoming season.

Season 3 premieres on Monday, January 12. Or, if you can't wait, you can watch the opening episode right now.

I've only seen the 10 minutes, but it looks like it'll be good entertainment if you are in the mood for teen angst (prom night!) mixed with your SF. You can see full episodes from the first two seasons on the ABC Family web site. (Note: as of 2012 the free episodes of Kyle XY are unfortunately no longer available.)
(I was going to discuss Kyle's missing belly button, but this post is long enough already. Maybe I'll get to it later in the season.)

Monday, December 01, 2008

The Planet of the Apes Movie that Never Was and the Movie that Will Be

Since the first Planet of the Apes movie was released in 1968, there have been four sequels and a short-lived television series. Tim Burton made a reimagined version of the original in 2001. In all of those versions, the intelligent apes that rule the planet turn out to be descendants of present-day Earthly apes.

According to Devin Faraci at Chud.com, there might have been a very different sequel, if Oliver Stone had had his way:
Talking to Entertainment Weekly in 1993, [Stone] said ''My concept is there's a code inscribed in the Bible that predicts all historical events. The apes were there at the beginning and figured it out. I don't want to (say) too much more, except the stars will be hairy.''

The idea was that a disease was wiping out the human race today. Arnold Schwarzenegger would play Will Robinson (I don't think this was meant as a Lost in Space tie-in, but who knows with this batty shit) as a genetic scientist who figures out the cause of the disease is in the distant past and, along with a pregnant colleague, travels back to the Stone Age to discover a world dominated by apes. To stop the plague they save a girl named Aiv. The time-traveling woman has a son named Adam.
That sounds pretty bad - from the Bible Code that's apparently hundreds of thousands of years old and created by apes, to the time traveler who becomes "Adam". It might have been amusing to see Schwarzenegger as a geneticist, but probably not worth sitting through a 3-hour-long Oliver Stone ape epic. We should all be grateful that the movie eventually fell into Tim Burton's creative hands.

It turns out there is Planet of the Apes prequel in the works, and writer/director Scott Frank plans to make it a hard science fiction movie. It will be set in the near future, and tell the story of Caesar, an "uplifted" chimpanzee with genetically enhanced intelligence who will become the ancestor of the apes who will eventually rule the world.
The science that creates a hyper-intelligent chimpanzee is based on current real world research - this film would just take that science one step further. He's also committed to telling a story based on character, not antic ape action. His plan for Caesar is one where you come to really feel for this ape, even as the final act sees him taking actions that may be hard for us to agree with.

[. . .] Since he doesn't want to have people running around in monkey suits, Frank is doing lots of research into the state of effects today - can he create a photoreal chimpanzee (one who is facially modified by the genetic engineering that grants him his intelligence) who will be the main character for this film? Can he create a character who is completely expressive through his face, eyes, and gestures (including sign language) without speaking a word of dialogue?
It sounds like an interesting idea. Lack of dialogue shouldn't be a problem, at least in principal - just look at how successful the robots in WALL-E conveyed emotion, despite their lack of facial features. However, I think a sort of chimp-human hybrid could be tricky to pull off, because it's almost-but-not-quite-human features might land the character deep in the uncanny valley. If Frank is successful, it might open the door to movies set in Brin's Uplift Universe, which I think would be awesome.

As for the science, we really are in the very early stages of understanding how genetics influence intelligence. Since both human and chimpanzee genomes have been sequenced, scientists have started to tease out what the differences in DNA sequence between our species mean at a functional level. Some intriguing possibilities have emerged, but I think we are a long way from being able to genetically engineer enhanced intelligence in either humans or chimps. That's not to say it won't be possible someday, but certainly not in the next couple of years.

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Friday, October 17, 2008

Big Giant Heads

talosians
She studied him for a long moment. He was twice her size, with an enormous head. Yet his ears were small and his nose was stubby, like an afterthought. "Yes, they were more our size. Their heads were human and –"
"Ur-human," the man corrected absently, as though he was distracted.
"What?"
"Oh, I am sorry, We term your kind Ur-human, since you are the earliest form available."
Her mouth whitened. "And what do you call yourselves?"
"Ah, humans," he said uncomfortably.
~ Beyond the Fall of Night, Arthur C. Clarke and Gregory Benford.
Before transhumanism became all the fashion, science fictional depictions of far future often gave our human descendants fantastic mental powers along with giant brains. But there is a serious problem with that idea: human brain size at birth is limited by the size of the opening in the pelvis, and those far future women never seem to have extra-wide hips to go along with their giant heads. A solution, of course, is assume that human birth will ultimately require medical technology. And it appears possible that even technology we use today might allow humans to start heading down that evolutionary path.

At The Panda's Thumb PZ Myers looks at the suggestion that the wide availability of relatively safe Cesarean sections in developed countries allows the evolution of bigger-headed humans.
Babies have very big heads that squeeze with only great difficulty through a relatively narrow pelvis, so the relationship in size between head diameter and the diameter of the pelvic opening has been a limitation on human evolution. We know this had to be a factor in our evolution: the average newborn mammal has a cranial capacity that is roughly 50% of the adult size, chimpanzee babies have heads about 40% of the adult size, but human babies have crania that are only 23% of what they will be in adults. While our brains have gotten larger over evolutionary time, they have not gotten proportionally larger in utero, because large-headed babies increase the difficulty of labor and cause increased mortality in childbirth. If childbirth could bypass the pelvic bottleneck, that would allow for fetal heads to grow larger without increasing the risk of killing mother and/or child.
There is some circumstantial evidence that bigger babies are being born in the US, and that the increased size has a genetic component. That's certainly not proof that humans are evolving along those lines, but it does make the idea plausible.

But is bigger necessarily smarter? Given a similar genetic background larger brain size doesn't seem to improve cognitive abilities. It's the connections between neurons that have the greatest effect on brain function. A recent review of human brain evolution described some of the other potential problems of increasing brain size.
For one thing, a big brain is a metabolic drain on our bodies. Indeed, some people argue that, because the brain is one of the most metabolically expensive tissues in our body, our brains could only have expanded in response to an improved diet. Another cost that goes along with a big brain is the need to reorganise its wiring. “As brain size increases, several problems are created”, explains systems neurobiologist Jon Kaas (Vanderbilt University, Nashville, Tennessee, United States). “The most serious is the increased time it takes to get information from one place to another.” One solution is to make the axons of the neurons bigger but this increases brain size again and the problem escalates. Another solution is to do things locally: only connect those parts of the brain that have to be connected, and avoid the need for communication between hemispheres by making different sides of the brain do different things. A big brain can also be made more efficient by organising it into more subdivisions, “rather like splitting a company into departments”, says Kaas. Overall, he concludes, because a bigger brain per se would not work, brain reorganisation and size increase probably occurred in parallel during human brain evolution. The end result is that the human brain is not just a scaled-up version of a mammal brain or even of an ape brain.
So our brains may get bigger, but they won't necessarily get better. And while both brain size and intelligence are both influenced by genetics, we haven't yet found any genes that affect both characteristics. For example, two genes that affect brain size, ASPM and Microcephalin, appear to have been evolving adaptively in modern human populations, there is no consistent correlation between the different genetic variants and IQ. But there is a correlation between specific variants of those genes and populations that use tonal languages, so perhaps their effect on brain function is more subtle than development of intelligence.

So will humans evolve Talosian-like giant brains? There is no way for us to know. What we can say is that elimination of the requirement for that babies' heads pass through the pelvis makes that development more plausible. And even if humanity does become big-headed, we may not end up any smarter - and almost certainly not psychic.

There is more discussion at Pharyngula.

Related Articles:
Bradbury J. "Molecular Insights into Human Brain Evolution" PLoS Biol 3(3):350 (2005)
doi:10.1371/journal.pbio.0030050

Mekel-Bobrov N. et al. "The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence." Hum. Mol. Genet. 16(6): 600-608 (2007)
doi:10.1093/hmg/ddl487

Schoenemann PT et al. "Brain size does not predict general cognitive ability within families." PNAS 97(9):4932-4937 (2000)

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Saturday, October 11, 2008

Biology in Science Fiction Roundup: October 11 Edition

Once again it's time to clean out my accumulated links:

Written Word

Suvudu takes a look at another frequently banned book: Flowers for Algernon.

The Guardian Books blog asks whether science fiction really needs to be so glooomy:
The world needs warnings from its future, and science fiction has been there to provide them. But there are no end of reasons to have hope for tomorrow. Biotechnology and genetic research offer fantastic advances in medicine, yet their portrayal in science fiction is typified by the gloom of Margaret Atwood's Oryx and Crake. [...] To look at the infinite possibilities of the future and see only darkness is a failure of imagination.
Rudy Rucker talks about sex and science fiction.

Movies

Warner Bros. plans a prequel to I Am Legend. Will Smith will reprise his role as a virologist who is one of the few survivors of a plague caused by a mutant engineered virus.

Jeff Carlson's thriller Plague Year will be made into a feature film

io9 reports that there will be a significant difference between the comic book version of Y The Last Man and the movie adaptation of the story.
First of all, we are going to lose all the interesting subplots about how the political regimes of the world reconstitute themselves in the wake of losing every single creature with a Y chromosome. We'll get very few chances to learn about the Israeli military, the Amazonian terrorists, the Japanese all-girl Yakuza, the women's prison-turned-farm-coop, and the female scientists working to make it possible to rebuild the world out of the DNA they've got left. In other words: A comic book about a world entirely filled with women is going to turn into a movie about a dude.
Is it possible that a movie with a single male character will end up failing the Bechdel Test?

Television

Jennifer Oullette at Cocktail Party Physics took a look at the science-based shows appearing on prime time

At The Bones Blog Vanessa Uy looks at the Anthropology of Star Trek (via SF Signal)

AMC has announced that it will be adapting Kim Stanley Robinson's Red Mars. It's not clear if it will be a movie or mini-series. I hope the latter.

Web Series

io9 has an interview with Joshua Fialkov about his web series LG15:The Resistance, an unlikely spin-off to lonelygirl15.

io9: LG15: The Resistance is, oh, roughly a million miles away from what people think of when they think of lonelygirl15, in part because the mainstream hype for that really peaked before the series' revelation of a wider, more SF and fantasy-based mythology. Is it a problem when you explain to people that this series isn't really just a girl sitting in front of her webcam at home, talking about her life, but instead all about secret societies and genetically superior beings?

Joshua Fialkov: Yeah, I definitely think there's a huge audience out there that would love the show if they just knew what it really was.

Theatre

Watch video of The Fly:The Opera at io9

Cool Science

The Times reports that geneticist Steve Jones says that "human evolution is over". His claims have been refuted in so many places that there is nothing for me to add. Read more: John Hawks, Gene Expression, Evolving Thoughts, discussion at Sandwalk.

io9's biogeek looks at whether human evolution will result in beings of pure energy (sadly, no)

Carl Zimmer writes about the latest research on genes and intelligence (so far not much progress). He also has an an article in Conservation Magazine about "The Most Popular Life Style on Earth" - parasitism!

Kevin Kelly discusses why he doesn't think the singularity will happen, at least not in the way Kurzweil has described it: thinking, even really fast thinking by an AI, isn't sufficient to solve our problems. The assumption that it is sufficient he terms "thinkism". (via Futurismic)
Let's take curing cancer or prolonging longevity. These are problems that thinking along cannot solve. No amount of thinkism will discover how the cell ages, or how telomeres fall off. No intelligence, no matter how super duper, can figure out how human body works simply by reading all the known scientific literature in the world and then contemplating it. No super AI can simply think about all the current and past nuclear fission experiments and then come up with working nuclear fusion in a day. Between not knowing how things work and knowing how they work is a lot more than thinkism. There are tons of experiments in the real world which yields tons and tons of data that will be required to form the correct working hypothesis. Thinking about the potential data will not yield the correct data. Thinking is only part of science; maybe even a small part. We don't have enough proper data to come close to solving the death problem. And in the case of living organisms, most of these experiments take calendar time. They take years, or months, or at least days, to get results. Thinkism may be instant for a super AI, but experimental results are not instant.
We are still finding alien creatures that exist right here on Earth. An example of this is the newly characterized Desuforudis audaxviator, which lives deep in a gold mine nearly 3 kilometers beneath the surface of the Earth. There is no light, little air and an ambient temperature of 160°C (140°F). It lives on the hydrogen and sulfate produced by the radioactive decay of uranium.
"One question that has arisen when considering the capacity of other planets to support life is whether organisms can exist independently, without access even to the sun," says Chivian. "The answer is yes, and here's the proof. It's sort of philosophically exciting to know that everything necessary for life can be packed into a single genome."
Nina Munteanu looks at growing fuel from algae.

Genetic Future reports that a new company, Complete Genomics, has promised to provide whole-genome sequencing for only $5000 by the middle of next year. The perfect Christmas gift?

In what is a grossly misleadingly-headlined post, SciFi Scanner says "Scientists say our eyes evolved to see through objects". Um, no, our binocular vision allows us to integrate information from both eyes, so if our right eye can see behind the right side of an object and our left eye can see behind the left side of an object, our brain can piece together that information into an image of what is "behind" the object.

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Tuesday, September 30, 2008

Biologically Uplifting NonHuman Animals and Ethics

Project Uplift? Oh yes. I remember hearing about this.

It had been featured in the news, a year or two ago. Both professional and amateur media had swarmed over a small group of "kooks" whose aim was to alter several animal species, giving them human-level intelligence. Foes of all kinds had attacked the endeavor. Religions called it sacrilegious. Eco-enthusiasts decried meddling in Nature's wisdom. Tolerance-fetishists demanded that native dolphin "culture" be left alone, while others rifkined the proposal, predicting mutants would escape the labs to endanger humanity. One problem with diversity in an age of amateurs was that your hobby might attract ire from a myriad others, especially those whose particular passion was indignant disapproval, with a bent for litigation.

This "Uplift Project" could not survive the rough-and-tumble battle that ensued. A great many modern endeavors didn't.

~ "Aficionado" by David Brin

When I hear the term "uplift", at least in the context of biology, I think of David Brin's Uplift universe. In those stories humans have genetically manipulated chimpanzees and bottlenose dolphins so that they achieve sapience. As genetic engineering technology and our understanding of the basis of intelligence improves, it becomes more likely that society will have to grapple with the ethical implications of such experimentation. As suggested by the excerpt above, even in Brin's fictional future animal uplift was both ethically and scientifically controversial.

While I don't personally believe that such uplift will take place in the immediate future, I do think it is worthwhile topic to discuss the implications of such experimentation. Futurist and bioethicist George Dvorsky has, in fact, addressed some of those topics in a provocative paper about "developmental and ethical considerations for biologically uplifting nonhuman animals"*. He argues that not only should we be allowed to uplift nonhuman animals, but also that we have a moral obligation to do so.

As many transhumanists and technoprogressives are inclined to point out, human enhancement offers an unprecedented opportunity for the human species to transcend biological limitations. These include not just the benefits of what may be gained, but also the benefits of what may be discarded.

[. . .]

Given the animal rights movement's goal to increase the moral circle to include higher animals, and given that a strong scientific case can be made in favour of animal personhood, a time will come for humanity to conclude that what is good for the goose is also good for the gander. Furthermore, it would be unethical, negligent and even hypocritical of humans to enhance only themselves and ignore the larger community of sapient nonhuman animals. The idea of humanity entering into an advanced state of biological and/or postbiological existence while the rest of nature is left behind to fend for itself is distasteful.

Why uplift nonhuman animals? What is it that we hope they will gain? Ultimately, the goal of uplift is to foster better lives. By increasing the rational faculties of animals, and by giving them the tools to better manage themselves and their environment, they stand to gain everything that we have come to value as a species.

Some of Dvorsky's arguments seem to tread close to the idea that animals should be treated equivalently to humans, which I find troubling. It is similar attitudes that have lead to the recent terrorist attacks against biologists. I'm not suggesting that Dvorsky advocates such violence, but he does apparently approve of the legislation in New Zealand and Britain that has banned research on great apes, and essentially considers them equivalent to humans. The irony is that legislation that raises nonhuman animals to the status of "persons" may lead to the abandonment of the neuroscience research necessary to actually develop the techniques for uplifting nonhuman animals to sapience. Dvorsky also argues that his philosphy is non-anthropocentric:

The idea that nonhumans should be uplifted so that they more closely resemble Homo sapiens has been interpreted as a rather anthropocentric perspective. As already stated, the goal is not to transmutate animals in humans, but to improve their quality of life by endowing them with improved modes of functioning and increased health. If anything, the uplift argument is intellicentric and even quasi-perfectionist. Moreover, uplift is primarily advocated by transhumanists who also make the case for Homo sapiens to move beyond human limitations – a rather non-anthropocentric position.

Dvorsky seems to assume that uplifting nonhuman animals necessarily will improve their quality of life. Who are we to say that nonhuman animals live lives of less quality simply because their intelligence is not equal to ours? And sapience is no guarantee of a better quality of life; many humans suffer from hunger, ill health, and homelessness. I'm skeptical that transhumanist-style enhancements will be a fix for those problems, at least in the short term. And since I am anthropocentric, I think that determining how to improve the lives of our fellow humans should be a much higher priority than "uplifting" our nonhuman cousins.

Read: Dvorsky G. "All Together Now: Developmental and ethical considerations for biologically uplifting nonhuman animals" Journal of Evolution and Technology 19(1):129-142 (2008)

Read free short stories set in Brin's Uplift universe:
(via Sentient Developments)

Image: Rock ape investigates postcards by Between a Rock on Flickr
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Saturday, September 06, 2008

Biology in Science Fiction Roundup: September 6 Edition

Here are some of the bioscience and science fiction-related articles and blog posts I've been reading the past few weeks. It seems like there are a lot of entries this time. Is that a sign that summer is over? Or maybe I'm just not blogging enough.

Written Word

Watch the teaser trailer for Nancy Kress's Dogs at YouTube.

io9 rounds up novels in which intelligent design is truth:
This is the truly proscience version of ID theory: The notion that humans will eventually live in an ID universe, where our bodies and everything around us is designed. Only it will have been designed by us, in the service (hopefully) of bettering humanity. We won't be the playthings of some third party entity whose motivations are unclear. In the end, we will become our own intelligent designers.
Cheryl Morgan writes at The Bilerico Project about science fiction novels with transgender themes (via io9).

Nature Editor Henry Gee notes that the journal's short science fiction column, Futures, seems to confuse some people who are unclear on the whole fiction concept. If you have access to Nature online you can read the latest Futures, if not, you can read some of the past entries at concatenation.org

The Flowers For Algernon blog is republishing Daniel Key's classic novel in blog format. While the diary format of the original story is easily translated into blog format, the fact that the most recent post is at the top of the page (and the blogger doesn't have individual page posts) means that you have to scroll up to read, which is awkward. (via Metafilter)

Morgan Locke at Eat Our Brains points to data showing that the oceans are dying: Kate
Kate Wilhelm has a short story called “The Chosen.” It depicts the forests of the future, which have fallen silent. And still we mine them. This table is a glimpse at the reality that story predicted.
Lauren Davis at io9 tackles the question "When are Vampires Science Fiction?"

Movies

io9 rounds up the poor reviews of the movie version of Jose Saramago's dystopian novel Blindness

io9 also has info about the new French horror movie Mutants

Bloody Disgusting reports that director Guillermo del Toro has a number of new movies on his schedule after he completes The Hobbit, including remakes of Frankenstein, Dr. Jekyll and Mr. Hyde, and Slaughterhouse-Five, a movie version of Dan Simmon's Drood, and more.

SciFi Scanner writes about science fiction Venusians in book and film.

BoxOfficeProphets writes about the upcoming movie version of The Time Traveler's Wife

Wired interviews Leland Chee, keeper of the Star Wars Holocron - the database of all official information about the Star Wars universe. I didn't even know there was an Endor Holocust. Poor Ewoks.

Television

The Science Not Fiction blog writes about the creepy crawlies from the Eureka mummy episode in "Putting the Crypt in Cryptobiosis"

Brian Switek @ Laelaps writes about the ridiculous situation where an episode of the History Channel's Jurassic Fight Club - ostensibly a science program - uses science fiction/thriller novelist Steve Alten as an expert on prehistoric sharks (presumably on the strength of his novel about one), rather than actual shark experts. The result is a show that's closer to fiction than science:
. . . even worse is that we hear the same old tripe about the possibility that C. megalodon is still alive somewhere in the ocean depths. I haven't studied the history of this claim in modern fiction in detail but it did come up in JAWS, and numerous "so bad it's almost good" novels have been penned on just this premise (i.e. the MEG series, Extinct, Quest for Megalodon, Carcharodon, From the Dark Below, and Megalodon. I won't even get started on all the direct-to-video "Meg" movies...). Alten, of course, is the person who tells us of this shocking news (not like he's trying to get a movie made on the premise or has another book about it or anything...). Brett Kent throws some cold water on the idea, but then we get another clip with Alten saying that it's "wrong to assume" that his favorite monster isn't still out there somewhere. Yes, yes, "teach the controversy" and all that...
io9 interviews special effects artist Dan Rebert, whose gives the scoop on the fang physiology he used for the new HBO series True Blood.

Other Media

Dinosaur Comics on what the prehistoric past might really have been like (dragons and unicorns and butt hands!)

Seed Magazine takes a look at the way video games are reshaping how we perform and promote science, particularly biology.

The LA Times has an article about the LA Opera's collaborations between film and opera, including "The Fly"

Cool Science

Irradiatus at Biochemical Soul has a great post on developmental biology, transhumanism and building a better human

Ask Metafilter collects examples of transhumanism in the real world - nothing quite as cool as the movies.

io9's Biogeek lists the unlikeliest futures for the human species.

Mo at Neurophilosphy writes about the neuroscience of magic, and points to the (freely available) article at Nature Reviews Neuroscience "Attention and awareness in stage magic: turning tricks into research" and accompanying videos of magician demonstrations from the "Magic of Consciousness Symposium".

TED has posted a video of Paul Rothemund's talk on DNA folding, a process he hopes to use to "create tiny machines that assemble themselves from a set of instructions"

Wired posts about a new gene therapy that stimulates growth of inner ear hairs. Loss of those hairs can cause a range of problems, from tinnitus to deafness, so this is an exciting result, even if it has only been performed in mice.

PZ Myers explains a recent paper that demonstrated the reprogramming of adult pancreas cells by the introduction of three transcription factors.

Engineers at MIT have developed a method of building microbatteries using self-assembling viruses.

Meanwhile, scientists at Caltech have created a "super-compact high-resultion microscope, small enough to fit on a finger tip." Not only is it small enough to fit on a fingertip, it's cheap: $10 for a mass-produced version.
In the future, the microscope chips could be incorporated into devices that are implanted into the human body. "An implantable microscope analysis system can autonomously screen for and isolate rogue cancer cells in blood circulation, thus, providing important diagnostic information and helping arrest the spread of cancer," says Yang.
Jake Young at Pure Pedantry writes about the recent review in Nature on anti-aging science. It's probably not good news if you were hoping for a pill to help you live to 200.

At io9 Annalee Newitz reports on a protein that can prevent telomeres - the "caps" at the end of chromosomes - from shortening over time. The result is cells that retain their "youth", which perhaps will someday be part of a longevity treatment.

Live Science suggests that there are evolutionary advantages to being a little bit mentally ill.

Dark Roasted Blend has photos of the most alien-looking place on Earth (via Posthuman Blues)

Watch a video of Michael Chorost speaking as part of the Authors@Google series about becoming a cyborg:
Michael Chorost became a cyborg on October 1, 2001, the day his new ear was booted up. Born hard of hearing in 1964, he went completely deaf in his thirties. Rather than live in silence, he chose to have a computer surgically embedded in his skull to artificially restore his hearing. This is the story of Chorost's journey -- from deafness to hearing, from human to cyborg -- and how it transformed him. The melding of silicon and flesh has long been the stuff of science fiction. But as Chorost reveals in this witty, poignant, and illuminating memoir, fantasy is now giving way to reality.
Keven at The Other 95% writes about a new species discovered in a piece of amber purchased through Ebay.

Robert Sawyer writes about the latest news on Neanderthals.

Scientists at MIT show how insects use trapped air bubbles to breath under water.

Ed at Not Exactly Rocket Science writes about a recent study that shows how European genes mirror European geography.

Scientific American has an article about animal intelligence and the evolution of the human mind.

a Nadder posts about the Aliens Among Us - life on Earth that is at least as strange as fictional extraterrestrials.

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Wednesday, July 09, 2008

Engineering a Higher IQ?

Kosmo at Genes and Demons points out the 2007 thesis of María Florencia Gosso, "Common Genetic Variants Underlying Cognitive Ability" (pdf) as research to watch.
I've yet to read it in detail, but a quick scan reveals dozens of genes which have been shown to have small cumulative impacts on IQ (with average differences between various alleles being in the two to four point range). The most significant difference I saw was between the two versions of the ADRB2 gene. In humans there exists two non-synonymous coding SNP's (rs1042713 and rs1042714) for this gene. The 713 version conferred a whopping eight point increase in average verbal IQ.
ADRB2 is more commonly known as the beta-2 adrenergic receptor, which is activated by adrenalin and noradrenalin (also known as epinephrine and norepinephrine). Even though the primary role of the receptor is regulation of smooth muscle relaxation, the receptor is also expressed in the central nervous system, and some studies have suggested that it plays a role in memory and learning formation. Interestingly the rs1042713 allele is a human-specific variant differing by a single amino acid from the "ancestral" protein sequence.

But does that really mean we've cracked the code for the genetic basis of intelligence? Not exactly. While there was an 8 point verbal IQ difference between individuals that varied at this allele, the author cautions that there could be "possible inflation of the estimated genetic effect sizedue to the relatively small sample size." Also, because intelligence appears to be affected by many genes it is unknown whether variation of the beta-2 adrenergic receptor sequence would have the same effect in all genetic backgrounds. And, of course, the question of whether the sequence variation affects the receptor's function in smooth muscle tissue has not been addressed. But that's the nature of scientific research. No one study provides all the answers, and this particular study points to an interesting direction for follow-up research.

Someday we may look back and indeed acclaim Gosso's research as a turning point in human genetic research. Only time - and further experiments - will tell.

Note: I did a search of PubMed and this portion of Gosso's thesis does not appear to have been published yet.
Image: 3D representation of the beta2-adrenergic receptor (via
Science).

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Thursday, April 03, 2008

David Brin on Uplifting Animals

French site ActuSF interviewed David Brin, and he talked a bit about increasing the intelligence of non-human animals:
ActuSF : You made also animals endowed with "conscience" as dolphins and chimpanzees. Do you think that one day science will go that far ?
David Brin : Yes, I do. But will we make them slaves, as shown by Pierre Boule or HG Wells ? Or will we try to make them citizens, as in my Elevation Universe ? First we must be the ones with a conscience !
[snip]

ActuSF : How not to make too much anthropomorphism with these animals or ET ?
David Brin : You must study the research and talk to experts who work with these animals, in order to make sure this "essence" remains !

ActuSF : Is it possible to make them behave in a manner truly different and without taking humans as a point of comparison ?
David Brin : You can never do this perfectly, so I have my characters discuss this ! Some of them worry : "Am I becoming too human ?"
While he doesn't have a new novel set in the Uplift Universe currently in the works, he points interested readers to his 1998 novella "Temptation", which you can read for free at DavidBrin.com. As he describes the story:
Completists eager for more in the Uplift Universe may be interested in reading the novella "Temptation," which appeared in Robert Silverberg's anthology Far Horizons: All New Tales from the Greatest Worlds of Science Fiction. This work features the adventures of a female dolphin on the faraway world, Jijo, who must escape from two of her own kind and then penetrate a deeply dangerous ancient secret. This novella will be a core element of the next Uplift novel... when I get around to it (!)... and answers several unresolved riddles left over from Heaven's Reach.
His most recent novel is Sky Horizon, the first in a series of "Colony High" novels.

(via SF Signal; Image: "Dolphin Encounter" by Just Taken Pics on flickr)
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Monday, March 31, 2008

Good News for Mrs. Frisby

Japanese scientists have taught degus - rat-like rodents - to use a rake to obtain food.


Technovelgy points out the similarity of the tool-using degus to the intelligent rodent-like creatures in H. Beam Piper's Little Fuzzy, and the Watchmakers in The Mote in God's Eye by Larry Niven and Jerry Pournelle.

The first fictional reference that sprang to my mind was Robert O'Brien's Mrs. Frisby and the Rats of NIMH, one of my childhood favorites. In that story, rats escape from the National Institute of Mental Health, where they were part of an intelligence-enhancing experiment. They end up on a farm where the mouse Mrs. Frisby lives. The rats use their superior intelligence and ability to use tools - not just raking, but building motors and the like - to help move Mrs. Frisby and her sick son to a new home before their old one is destroyed. The NIMH rats are both smart and dexterous. I wonder if the degus can top that?



My previous post on the biology in Mrs. Frisby and the Rats of NIMH.

Download Little Fuzzy for free from Project Gutenberg.

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Wednesday, January 30, 2008

Talking Squids in Outer Space

This week's Sci Fi Weekly web site of the week is Talking Squids form Outer Space. The content is pretty what you'd expect from the title: science fiction featuring squids and other cephalopods. There is a squidliography, of course, and even free SF stories featuring squids.

This current featured story is "Sheena 5" by Stephen Baxter, which stars a squid with enhanced intelligence working for NASA.

It came after the kill.

The night was over. The sun, a fat ball of light, was already glimmering above the water surface.

The squid emerged from the grasses and corals where they had been feeding. Shoals formed in small groups and clusters, eventually combining into a community a hundred strong.

Court me. Court me.

See my weapons!

I am strong and fierce.

Stay away! Stay away! She is mine! ...

It was the ancient cephalopod language, a language of complex skin patterns, body posture, texture, words of sex and danger and food; and Sheena shoaled and sang with joy.

... But there was a shadow on the water.

Go read the whole story.

It's not obvious from it's face, but Talking Squids in Outer Space is a subsite of SF writer Vonda McIntyre's official web site. It looks like she has another cool hobby, in addition to creating bead creatures. Her Nebula-winning novel,The Moon and the Sun, features giant octopuses. From the epilogue:
The sea people stalked the ships. Soon they swam beneath the barnacled bottom of the pursuer. Sherzad sang at it, feeling it out with her voice, searching and questioning, finding nothing of interest and nothing worth saving. In the past, she would have swum away.

She gave her baby to her young brother to guard, and swam closer to the pursuer.

Sherzad and her companions plunged their spears of narwhal tusk into the bottom of the galleon. The ivory bit into the wood. Holding the tusks, they rode along with the ship.

Sherzad shouted at the planks. Her focused voice crashed into the wood. She shouted again. Her spear quivered in the quaking wood. Sherzad and her brothers and sisters shouted together. The wood cracked and split.

The bottom of the ship disintegrated. Men shrieked and dove into the water. Sherzad and the others made sure they never surfaced.

Waves washed over the deck. Singing their triumph, the sea people called their allies. A shadow rose, flickering all over with tiny sparks. The octopus stretched its tentacles into the moonlight and entwined them around the mainmast, and inexorably pulled the ship into the depths.
Cephalopods and sea people working together in harmony. Beautiful.

And if you love squids and science fiction, you'll definitely want to get the SFWA "Squid Happens" T-shirt for your wardrobe. Proceeds go to the Science Fiction and Fantasy Writers of America's Emergency Medical Fund.

Image source: Squid with eggs @ NOAA.gov
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