Showing posts with label cryobiology. Show all posts
Showing posts with label cryobiology. Show all posts

Wednesday, April 22, 2009

Cold as Ice

The seduction of Ellsworth Stevens made a temporary stir in certain lofty circles, shocking all but the most cynical.

A brilliant bio-chemist, a few months previously Stevens had reported some attempts at suspending animation in mammals by a method involving preliminary partial dehydration of the living tissue through starvation, followed by freezing.

The technique exploited the newly-discovered tendency of very minute quantities of radioactive phosphorus in certain phospholipids to counteract the degenerative anti-gelation effect of low temperatures on the colloidal phases of protoplasm.

He had not succeeded in reviving any of the animals, since none of the nerve tissue had lived through the freezing, but results had been nonetheless promising. Now Stevens was employed by the Cancer Institute, consecrated to this most important work.

Until one evening a Tempter called at his modest home. His name, of course, was Jones.

"Dr. Stevens," said Garry, "I want you to quit your job and go back to work on suspended animation."

~ "The Penultimate Trump" by Robert Ettinger, 1948
Imagine you are dying of cancer or Parkinson's disease or simply old age. Imagine having your body and brain preserved until a cure was developed. Imagine then being reawakened in complete health.

That was the promise of Robert Ettinger's 1948 short story "The Penultimate Trump". The premise of frozen sleep became fodder for many a "man out of time" science fiction story, from Frederik Pohl's The Age of the Pussyfoot, to Woody Allen's Sleeper, to Bev Katz Rosenbaum's recent young adult novel I Was a Teenage Popsicle. And cold sleep has become a standard science fictional method for humans to endure long journeys between the stars.

But it isn't only science fiction. Ettinger published a non-fiction book on cryopreservation, The Prospect of Immortality, in 1962. And it wasn't long after that advocates of cryonics began selling such services. That was despite the fact that they had no idea whether their preservation techniques would adequately preserve frozen human tissue or when (and if) the technology would be developed for successful revival.

And some people were frozen long before a storage facility existed. That's part of the story of Bob Nelson, TV repairman, cryonics enthusiast and president of the Cryonics Society of California. In January of 1967, Nelson helped freeze the body of psychology professor James Bedford - the very first human intentially frozen in anticipation of later revival. Bedford's frozen body was transferred from Nelson's care after a week. That was fortunate for Bedford, because he is the only one of Nelson's "patients" who are still frozen today. It's not clear if Nelson was deluded or a charletain, but the fact is that he talked as if he had a cryonics system in place, when he did not:
Although he had made virtually no progress toward establishing a cryonics facility, early in 1969 Nelson gave an interview to Cryonics Reports magazine describing it as if it already existed. He claimed that individual cryopatients were stored in pods "very similar to the units that were used in 2001: A Space Odyssey," and the pods were immersed in giant containers 14 feet in diameter, each capable of holding 15 to 20 people. "Units are moved by a series of stainless steel cables that guide them into position, and they can be introduced and retrieved at will," he told the magazine. None of these statements was true. Nelson subsequently circulated photographs of himself standing beside a tank with "Cryonic Interment" lettered on the side, but its location remains unknown, and since it was intended only for bulk storage of liquid nitrogen, it would have been unsuitable for maintaining cryonics patients accessibly.
The other bodies in Nelson's care weren't maintained in a frozen state, and their decomposing bodies were eventually revealed in 1979. You can hear Nelson's story on a recently-posted episode of This American Life (or read about it here). Not surprisingly, the ensuing scandal resulted in regulation of the industry.

People who choose to be preserved shortly after death have real faith in the development of technology that will revive them. Alcor, one of the companies offering cryonic preservation today, acknowledges that revival technology "may become a reality a century or more in the future." And when and if revival technology does become available there's no guarantee that the preservation process used today will have adequately preserved their bodies. It's a leap of faith, or perhaps a real fear of death, that they will return to life.

Image: "Steel & aluminum cryo-capsule containing mylar-wrapped body, designed by wigmaker Edward Hope to store frozen body of James Bedford, re experimental cryonics", published in Life magazine in 1967.
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Tuesday, January 06, 2009

Ideas from Science Fiction are a Career Killer?

The December issue of Esquire Tom Junod profiled biologist Mark Roth, whose lab at the Fred Hutchinson Cancer Research Center studies suspended animation. Long term human hibernation is a staple of science fiction, particularly as a method for transporting people for the very long journeys necessary to traverse our galaxy at sub-light speeds.

The style of the Esquire article is pretty breezy, particularly if you are used to reading profiles of scientists in Science (or even the New York Times), so can be a bit hard to tell what bits are based on facts, and what Junod included because he liked the sound of it. That's why I'm not quite sure what to make of this:
Now, Mark Roth is a scientist. He's not a philosopher or a crank. He proves things, experimentally, according to the scientific method. In 2007, he got a MacArthur, so he's a genius, certified. [snip long description of Roth's appearance] He sometimes gives you a goofy double thumbs-up when he thinks he's proved his point, when he's proved that what he's talking about -- be it ball lightning or the philosopher's stone -- is not a crazy idea but rather a gamer. Still, he's got a lot of ideas, for a scientist, and some of them come from unusual sources, like tabloidy news reports and science fiction.

It's a weird thing about scientists -- you would think that they would love science fiction. But they don't. To admit that you get your ideas from science fiction, if you're a scientist, that's, like, career-threatening, man, just like it might be professionally risky to say you work in Mark Roth's lab, no matter how outlandish and game-changing its accomplishments. And so, yes, Mark Roth is a scientist. But he's a scientist in the way that you used to want to be a scientist when you were a kid, with weird substances -- dangerous substances, toxic substances, indeed the most toxic substances known to man! -- bubbling away in his lab, rather than a scientist in the way that most scientists are scientists, with NIH funding, a stack of grant applications to catch up on, and a commitment to pursue the one or two ideas that got them that precious federal funding to the death.
Now from where I sit, this reads like a tiny kernel of truth surrounded whole lot of stupid. Junod doesn't seen to have ever met a scientist or seen a lab, and he doesn't appear have a clue that even unusual scientific ideas owe credit to the research that has gone on before.

Take, for example, his description of Roth as having a lot of ideas "for a scientist". Most scientists I've met have lots of ideas. I suspect that Junod actually meant to write "Roth has lots of ideas I find really cool". And that's pretty much the theme of the whole article: Roth doesn't just punch the clock doing boring research like all those unimaginitive scientists with NIH grants. He's a maverick doing weird science who found creative ways to fund his work. He's like totally rad!

The jab about most scientists not loving science fiction falls along those lines. Some scientists love science fiction and some don't. Just like some scientists are of differening opionions on the entertainment value of murder mysteries and Tom Clancy novels. But the implication seems to be that scientists dislike SF because they can't use the ideas in their grant proposals, which is just stupid.

Which brings me to his next point:
"To admit that you get your ideas from science fiction, if you're a scientist, that's, like, career-threatening, man...".
Well yes, if all your scientific ideas are only based on science fiction and not on, you know, actual science, that would be a problem. Most science fiction is fiction first and science second. Nothing wrong with that, of course, but not really that useful for basing your research on.

I suspect that Roth's scientific ideas about inducing suspended animation actually are based on previous research and not just The Forever War, even though he did apparently have a lot of trouble getting them funded (but, like, NIH funds only boring unoriginal stuff, so, like, dude, it's better that he didn't get any grants). You'd never know that reading this article, though.

And I don't want to give the impression that I don't think Roth's research is interesting. It is. I'm just not keen on the way it's been framed as better than what other scientist have been doing because it's so science fictional.

(via Ansible)

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Saturday, December 13, 2008

Biology in Science Fiction Roundup: December 13 edition

It's been a while since I did a round up, so there are lots of links!

General SF

SF Signal has video of a 1997 discussion between Harlan Ellison, J. Michael Straczynski, Herb Solow and Yvonne Fern about the meaning of the terms "science fiction" and "SciFi". Be sure to read the comments too.

Livemint.com has an extensive article about the state of science fiction in India with a number of video interviews with Indian SF writers, including Indian Science Fiction Writers Association secretary (and frequent commenter here) Arvind Mishra, Mohan Sanjeevan, Nellai Muthu, YH Deshpande, and GS Unnikrishnan.

John Scalzi points out that Technology Changes, People Not So Much

Ursula LeGuin and George RR Martin appeared on the public radio show To The Best of Our Knowlege, and discussed the future of science fiction and the genre boundaries between fantasy and science fiction (via io9)

Written Word

There's a great post at Metafilter about John Wyndham (author of Day of the Triffids), including links to the BBC Four documentary "The Invisible Man of Science Fiction".

The 2009 One Book - One Edinburgh reading campaign will feature Sir Arthur Conan Doyle's The Lost World.

In 2009 it will also be 200 years ago that Charles Darwin was born, who also has ties to our city. It was during his study at the University of Edinburgh that he developed a keen interest in natural history, and it was here and around the Forth that the foundations for his theory of evolution were developed.

To mark this double celebration, it seems only natural that the 2009 reading campaign - The Lost World Read 2009 - will focus on Conan Doyle's classic adventure story, The Lost World, in which a group of explorers set out on an expedition to South America to prove that deep in the jungle there is a forgotten world where dinosaurs and other prehistoric animals still survive.

They will be distributing thousands of free copies of The Lost World with a special cover by Aardman Animations, as well as a comic book biography of the life of Charles Darwin.

Moira Gunn at ITConversations has posted her 2003 interview with Michael Crichton about his novel Prey.


Movies

Annalee Newitz at io9 has a detailed review of The Day The Earth Stood Still

BioethicsBytes has a discussion of the 2004 DeNiro cloning movie Godsend.

Chris Mooney writes about the new science-Hollywood venture, The Science and Entertainment Exchange.

At io9 Lauren Davis rounds up Science Fiction's Deadliest Plants

There will not, as rumored, be a sequel to I Am Legend, but plans for a prequel apparently are real.



Rich Handley has recently published Timeline of the Planet of the Apes: The Definitive Chronology. It sounds like it provides the background information on how the apes came into power on Earth, including a bunch of biology:
  • How the apes acquired sentience and the power of speech—while man descended into mute savagery
  • Where the plague that ravaged the planet originated, and the effects it had not only on man and ape, but on other creatures
  • The many unique simian and human cultures that spawned around the globe in the aftermath of a nuclear holocaust—and how the Statue of Liberty ended up in pieces on a desolate beach
Television

Science Not Fiction looks at the Stargate Atlantis episode "Remnants" and speculates on colonizing the galaxy by sending out pods with our DNA.

Science Not Fiction also discusses Skynet's bioweapon in this week's episode of Terminator: The Sarah Connor Chronicles.

Armchair Commentary has an interview with Primeval cast members Hannah Spearritt and Andrew Lee Potts.

About Eleventh Hour:
About Fringe:
Cool Bioscience

Mike Brotherton explains how to build a giant monster

Seed Magazine profiles Mac Cowell, the cofounder of DIYbio and "the biohacking hobbyist"

Invitrogen is sponsoring a new ScienceBlogs biotech blog, "What's new in life science research". A few interesting recent posts: "Genetically Modified Humans? No Thanks." and "Bizarre cloners and serious questions" by Marcy Darnovsky; "10 Things You Should Know About Cloning" by Hsien-Hsien Lei; and "Short, Euphonious, and Different: Clone is Born, 1903" by Alexandra Stern.

Japanese scientists were able to create clones from the nuclei of cells isolated from dead mice that had been frozen for 16 years. What made this particular experiment unique is that the mice had not been frozen using chemicals to protect cells from damage. That suggests that extinct animals for which frozen samples exist could be resurrected by cloning.

A virus carrying the DNA encoding a light-sensitive protein was introduced into the spinal chord of nerve-damaged rats. The infected cells produced the protein which allowed the scientists to restore the function of the neurons by pulsing them with light.

Jonah Lehrer at The Frontal Cortex explains that "Hell is a Perfect Memory"

Scientific American has an in-depth article about Peptide Nucleic Acids (PNAs), which "combines the information-storage properties of DNA with the chemical stability of a proteinlike backbone"

"The Big Picture" at Boston.com has a fantastic collection of micrograph images. The very very small is like an alien world. (via Hoyden About Town)

WebEcoist has pictures of 20 Strange and Exotic Endangered Species (via BoingBoing)

Zooillogix has video of spiders spinning webs in the microgravity environment of the space shuttle.

Ask Metafilter tackles the question of whether virulent microbes can survive in crypts.

Sequencing of the Neanderthal genome is about 50% complete, and the first draft should be completed "by year's end" the NewScientist reports. So far there is no evidence that prehistoric European humans regularly interbred with Neanderthals. Meanwhile,William Saletan at Slate asks "Should we resurrect the Neanderthals?"

The J. Craig Venter Institute has made the news again. This time they successfully manufactured the first synthetic yeast organism in a single step. Meanwhile, scientists have created a virus from scratch based on SARS.

Virginia Hughes posts about "Genes & Jazz", a collaboration between virologist Harold Varmus and his musician son Jacob.

A new type of giant squid with "elbows" has been caught on video.

The IRAM radio telescope has discovered a sugar molecule - glycolaldehyde - in a star-forming region of space where planets that can support life as we know it might exist.

Wired Science has the Top 10 Amazing Biology Videos

io9 looks at the winners of the International Genetically Engineered Machine (iGEM) competition

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Friday, January 11, 2008

Waking in the Future

In her current net.wars column for NewsWirelessNet, journalist Wendy Grossman reports on her visit to cryonics giant Alcor. She points out that many of the ethical issues that arise from freezing then thawing individuals have been tackled in science fiction.

I think the first time I ever heard of anything like cryonics was Woody Allen's movie Sleeper. Reading about it as a serious proposition came nearly 20 years later, in Ed Regis's 1992 book [Great Mambo Chicken and the Transhuman Condition]. Regis's book, which I reviewed for New Scientist, was a vivid ramble through the outer fringes of science, which he dubbed "fin-de-siècle hubris".

My view hasn't changed: since cremation and burial both carry a chance of revival of zero, cryonics has to do hardly anything to offer better odds, no matter how slight.

But it remains a contentious idea. Isaac Asimov, for example, was against it, at least for himself. The science fiction I read as a teenager was filled with overpopulated earths covered in giant blocks of one-room apartments and people who lived on synthetic food because there was no longer the space or ability to grow enough of the real stuff. And we're going to add long-dead people as well?

What kind of issue comes up when you mention cryonics. Isn't it selfish? Or expensive? Or an imposition on future generations? What would the revived person would live on, given their outdated skills. Supposing you wake up a slave?

Many of these issues have been considered, if not by cryonicists themselves for purely practical reasons then by sf writers. Robert A. Heinlein's 1957 book [The Door Into Summer] had its protagonist involuntarily frozen and deposited into the future with no assets and no employment prospects, given that his engineering background was 30 years out of date. Larry Niven's 1991 short story "Rammer" had its hero revived into the mind-blanked body of a criminal and sent out as a starship pilot by a society that would have calmly vaped his personality in its turn, and replaced it with the next one if he were found unsuitable (Niven was also, by the way, the writer who coined the descriptor "corpsicle" for the cryopreserved). Even Woody Allen's Miles Monroe woke up in danger.

Grossman argues that the cryonics companies do take the possibly negative ramifications of the technology to heart since their board members intend to be cryopreserved themselves. I suppose only time will tell.

And Grossman leaves out one of the positive cryonics stories: Futurama. Fry leaves his job as a 20th century New York pizza delivery boy and wakes in the year 3000 to find friendship and occasional love as an interplanetary delivery boy. To me that would be the best case scenario: waking in the future and finding your niche.


Wednesday, June 27, 2007

Made in EUReKA

If you've ever wanted nanobot-based shampoo or a contact lens video camera, check out the Made in Eureka web site. They've even got infomercials just like you see on late night TV, with the oohing and ahing audience and perky hosts. My favorite is the CryoKennel (only three easy payments of $49.99!) which freezes your dog for easy transport too and from home. Easy!

If you haven't guessed already, this is a promotional site for the SciFi series EUReKA, which has it's second season premier on July 10.

Sunday, June 24, 2007

Cool Bioscience Weekly Roundup

A few of the bioscience stories from the past week that I found interesting:

Astrobiology Magazine takes a look at recent speculation that plant life on Earth-like planets outside our solar system might be black.

Scienceroll has an interview with "Max Chatnoir" about his creation of Genomic Island and the genetic revolution in Second Life.

Matt Castle at Damn Interesting looks at the original "cryobiology" experiments that started in the 1950s by bringing frozen hamsters back to life.
The potential demonstrated by frozen-hamster research has yet to be fully realised, but perhaps one day Dr. Audrey Smith's groundbreaking efforts will lay the foundation for powerful new medical procedures. Indeed, a hot over-sized spoon might one day miraculously transform frozen human cadavers back into living, breathing, productive zombies to slave away in the mechanized underworld of the future. Until that long-hoped-for day arrives, perhaps– like James Lovelock– we can console ourselves with the idea that this pioneering work has helped broaden the meaning of life.
Reporter David Ewing Duncan gives a first-hand report to MIT Technology Review about chemicals and other treatments that claim to give your brain a boost. His conclusion:
Before long we might be drinking beverages laced with modafinil and other mild stimulants that have fewer side effects than coffee. It's likely that we'll also be slipping zappers onto the brims of our hats and flipping them on when we get spacey. But neither of these brain boosters is close to helping me, say, understand advanced quantum mechanics or write a symphony like Mozart. I'll have to muddle along being me for a bit longer.
Also in Technology Review, Emily Singer describes how scientists hope to use DNA sequencing and genetic engineering on variety of plants such as button mushrooms and eucalyptus trees to improve production of biofuels.

Wired talks about the genetic engineering of mushrooms for the production of pharmaceuticals.

New Scientist reports that biologist Keller Autumn and his colleagues at Lewis & Clark University have figured out how geckos stick to walls. What works for geckos hasn't worked for heavier machines.

"Scaling things up creates big problems," said Autumn. "We know it's a challenge none of the virtual gecko adhesives are capable of doing."

Nevertheless, he believes that with the development of strong carbon nanotubes and silicon nanowires that could used instead of gecko hairs, a comparable adhesive could become a viable option within the next 10 years.

In other nanotechnology news, bacteria have been harnessed as microscopic propellers.

Science Daily looks at the the "electric duets" used in the aquatic courtship of electric fish.

David Kerns, guest poster at Cognitive Daily, takes a look at what makes a movement seem "artificial." He looks at it from the movie special effects CGI angle, but the same issue arises when you think about human-alien interaction. How much of our perception would be governed by our unconscious expectations?
Body language is a critical form of communication for human beings. We can pick up a lot of meaning from physical movements, even when we only see a very limited amount of information about that movement. For example, most special effects animation is created by putting sensors on several parts of the human body to determine how body parts interact when the body is in motion. A human figure made up of just ten dots located in the different major body regions is enough to convey a wide range of emotions and complex physical movements. How does this work?
Did you know that 90% of the cells within us are microbes? Discover Magazine takes a look at the marvelous ecosystem that is the human body. In the same vein, MIT Technology Review takes a more in-depth look at "our microbial menagerie" and how they are important to our health.

Vaughan at Mind Hacks writes about the use of genetics to determine which psychiatric drugs "will be the most effective and least problematic."

Sandra Porter of Discovering Biology in a Digital World guides you through an animation of the Polymerase Chain Reaction (PCR).

R. Ford Denison writes about a recent publication that looks at whether plants can recognize "kin".

At the Loom, Carl Zimmer explains how the resistance our ancestors evolved to a virus in the Pleistocene might make us susceptible to HIV today.

Finally, Philip Ball at nature.com reports on "open source" vs. patented parts in synthetic biology.

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